منابع مشابه
Cardiac effects of tyramine.
• Tyramino (p-hydroxyphenylethylamine), the product of decarboxylation of tyrosine, has been known for a number of years to have pharmacological activity as a pressor substance." In a preparation of the atrium of the cat's heart in Locke-Ringer solution, Ajidrus, in 1 924, showed that tyramine increased the rate aud amplitude of atrial contractions. In 1926, Tainter reported the circulatory eff...
متن کاملPressor sensitivity to tyramine in patients with headache: relationship to platelet monoamine oxidase and to dietary provocation.
The pressor responses to oral and intravenous tyramine were not different from controls in migrainous patients with or without a history of attacks triggered by foods. However, patients who reported a dietary trigger were more likely to develop headache after tyramine administration than those without such a dietary history. Pressor responses to intravenous tyramine in patients with cluster hea...
متن کاملThe monoamine oxidase type B inhibitor rasagiline in the treatment of Parkinson disease: is tyramine a challenge?
Rasagiline is an irreversible monoamine oxidase type B (MAO-B) inhibitor indicated for the treatment of the signs and symptoms of idiopathic Parkinson disease as initial monotherapy and as adjunct therapy to levodopa. Pharmacologic inhibition of monoamine oxidase type A (MAO-A), but not MAO-B, poses a risk of the "cheese effect," a hypertensive response to excess dietary tyramine, a biogenic sy...
متن کاملTyramine and phenylethylamine biosynthesis by food bacteria.
Tyramine poisoning is caused by the ingestion of food containing high levels of tyramine, a biogenic amine. Any foods containing free tyrosine are subject to tyramine formation if poor sanitation and low quality foods are used or if the food is subject to temperature abuse or extended storage time. Tyramine is generated by decarboxylation of the tyrosine through tyrosine decarboxylase (TDC) enz...
متن کاملTyramine kinetics and metabolism in cirrhosis.
Hypertyraminemia is common in hepatic cirrhosis and correlates in severity with encephalopathy. The mechanism of cirrhotic hypertyraminemia has not been established. The alternative possibilities are increased production from tyrosine and impaired degradation by monoamine oxidase. This investigation determined the pharmacokinetics of tyramine after an intravenous bolus injections of [3H]-tyrami...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1931
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)76440-5